Ceftriaxone’s bactericidal aciton is achieved through inhibition of mucopeptide synthesis in the bacterial cell wall: It has a high degree of stability in the presence of beta-lactamases, both penicillinases & cephalosporinases
Ceftriaxone is effective against both gram positive & gram negative bacteria. Gram positive susceptibility includes certain staphylococcal & stretococcal organisms. Gram negative susceptibility includes bacteroides spp., Enterobacter spp., E.coliKlebsiella spp., Proteus ssp.,Pseudomonas aerogenosa & serratia spp.
Ceftriaxone is well absorbed following intramuscular injection and is widely distributed across organ system. In addition, it crosses the blood brain barrier and the blood placenta barrier.
Sulbactam is a beta-lactamase inhibitor. This grug is given in combination with beta-lactam antibiotics to inhibit beta-lacatmase, an enzyme produced by bacteria that destroys the antibiotics.
Dogs : 15 to 50 mg/kg every 12 to 24 hours by IM/IV route. Cats : 25 to 50 mg/kg every 12 hours by IM/IV route